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Re: serial API
https://www.tldp.org/HOWTO/Serial-Programming-HOWTO/
That howto should tell you everything you need to know about user-space programming of the serial port, also you might want to check out the "Other Sources of Information" section, for the POSIX guide.
IDT Quickswitch, the application note https://www.idt.com/docs/AN_11.pdf explains most of them, I encountered them also in the xilinx application note for interfacing there 3.3v VertexII to a 5v PCI bus https://www.xilinx.com/bvdocs/appnotes/xapp646.pdf
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