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If you are doing a straightforward digital design you shouldn't need to do spice simulations.
If you are doing a digital PLL, DLL, or anything that isn't latch to latch or FF to FF then you might want to simulate with SPICE models.
stew
Re: How many basic layers in CMOS layout besides metels?
There can be many variations of the different layers at a Fab. Different Vt's etc.. Read design rule documentation
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