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it denpends on what you want to design. You can first circuits smulation by eda tools, such as ADS, Cadence..., then use the layout tools: Cadence, Ledit...
first of all, you must make sure what frequcy band you want to use.
have fun
but in MW monolithic ic, it seems the 50 ohm can have the best performace, no reflection, so the 50 ohm coax resource not fit for MMIC or HMIC tech.
i think
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